Department of Radiology-Annual Executive Summary Report-July 1, 2008 to June 30, 2009

87 page Annual Executive Summary Report from Department of Radiology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States. Table of Contents: Department of Radiology Chairman, Vice Chairmen 1 Divisions and Directors 1 Committees and Chairmen 1 Radiology Department Faculty Rank 2 Faculty with Secondary Appointments 3 Clinical Divisions 4 Radiology Residents and Fellows 5 Department Organizational Chart 6 Department Administration Chart 7 State of the Department 8 Appendix I: Publications Journal Articles 21 Books and Book Chapters 29 Abstracts 30 Appendix II: Formal Scientific Presentations 40 Appendix III: Honors, Editorial Activities, Service to Regional or National Organizations 61 Appendix IV: Active Grants 74 Appendix V: Pending Grants 8

Department of Radiology-Annual Executive Summary Report-July 1, 2011 to June 30, 2012

93 page Department of Radiology Annual Executive Summary Report, July 1, 2011 to June 30, 2012, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States. Table of Contents Chairman, Vice Chairmen 1 Divisions and Directors 1 Committees and Chairmen 1 Radiology Department Faculty Rank 2 Faculty with Secondary Appointments 3 Clinical Divisions 4 Radiology Residents and Fellows 5 Department Organizational Chart 6 Department Administration Chart 7 State of the Department 8 Appendix I: Publications Journal Articles 23 Books and Book Chapters 31 Abstracts 35 Appendix II: Formal Scientific Presentations 50 Appendix III: Honors, Editorial Activities, Service to Regional or National Organizations 68 Appendix IV: Active Grants 82 Appendix V: Pending Grants 8

Value-Added Services of Hospital-Based Radiology Groups

Presentation at 97th Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA). Summary of presentation. 16 slides

Department of Radiology-Annual Executive Summary Report-July 1, 2010 to June 30, 2011

90 page Department of Radiology Annual Executive Summary Report, July 1, 2010 to June 30, 2011, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States. Tables of Contents: Department of Radiology Chairman, Vice Chairmen 1 Divisions and Directors 1 Committees and Chairmen 1 Radiology Department Faculty Rank 2 Faculty with Secondary Appointments 3 Clinical Divisions 4 Radiology Residents and Fellows 5 Department Organizational Chart 6 Department Administration Chart 7 State of the Department 8 Appendix I: Publications Journal Articles 22 Books and Book Chapters 30 Abstracts 33 Appendix II: Formal Scientific Presentations 44 Appendix III: Honors, Editorial Activities, Service to Regional or National Organizations 63 Appendix IV: Active Grants 77 Appendix V: Pending Grants 8

Department of Radiology-Annual Executive Summary Report-July 1, 2009 to June 30, 2010

86 page Annual Executive Summary Report from Department of Radiology, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States Table of Contents: Department of Radiology Chairman, Vice Chairmen 1 Divisions and Directors 1 Committees and Chairmen 1 Radiology Department Faculty Rank 2 Faculty with Secondary Appointments 3 Clinical Divisions 4 Radiology Residents and Fellows 5 Department Organizational Chart 6 Department Administration Chart 7 State of the Department 8 Appendix I: Publications Journal Articles 21 Books and Book Chapters 28 Abstracts 30 Appendix II: Formal Scientific Presentations 39 Appendix III: Honors, Editorial Activities, Service to Regional or National Organizations 59 Appendix IV: Active Grants 73 Appendix V: Pending Grants 7

Utilisation of an operative difficulty grading scale for laparoscopic cholecystectomy

Background A reliable system for grading operative difficulty of laparoscopic cholecystectomy would standardise description of findings and reporting of outcomes. The aim of this study was to validate a difficulty grading system (Nassar scale), testing its applicability and consistency in two large prospective datasets. Methods Patient and disease-related variables and 30-day outcomes were identified in two prospective cholecystectomy databases: the multi-centre prospective cohort of 8820 patients from the recent CholeS Study and the single-surgeon series containing 4089 patients. Operative data and patient outcomes were correlated with Nassar operative difficultly scale, using Kendall’s tau for dichotomous variables, or Jonckheere–Terpstra tests for continuous variables. A ROC curve analysis was performed, to quantify the predictive accuracy of the scale for each outcome, with continuous outcomes dichotomised, prior to analysis. Results A higher operative difficulty grade was consistently associated with worse outcomes for the patients in both the reference and CholeS cohorts. The median length of stay increased from 0 to 4 days, and the 30-day complication rate from 7.6 to 24.4% as the difficulty grade increased from 1 to 4/5 (both p < 0.001). In the CholeS cohort, a higher difficulty grade was found to be most strongly associated with conversion to open and 30-day mortality (AUROC = 0.903, 0.822, respectively). On multivariable analysis, the Nassar operative difficultly scale was found to be a significant independent predictor of operative duration, conversion to open surgery, 30-day complications and 30-day reintervention (all p < 0.001). Conclusion We have shown that an operative difficulty scale can standardise the description of operative findings by multiple grades of surgeons to facilitate audit, training assessment and research. It provides a tool for reporting operative findings, disease severity and technical difficulty and can be utilised in future research to reliably compare outcomes according to case mix and intra-operative difficulty

Population‐based cohort study of outcomes following cholecystectomy for benign gallbladder diseases

Background The aim was to describe the management of benign gallbladder disease and identify characteristics associated with all‐cause 30‐day readmissions and complications in a prospective population‐based cohort. Methods Data were collected on consecutive patients undergoing cholecystectomy in acute UK and Irish hospitals between 1 March and 1 May 2014. Potential explanatory variables influencing all‐cause 30‐day readmissions and complications were analysed by means of multilevel, multivariable logistic regression modelling using a two‐level hierarchical structure with patients (level 1) nested within hospitals (level 2). Results Data were collected on 8909 patients undergoing cholecystectomy from 167 hospitals. Some 1451 cholecystectomies (16·3 per cent) were performed as an emergency, 4165 (46·8 per cent) as elective operations, and 3293 patients (37·0 per cent) had had at least one previous emergency admission, but had surgery on a delayed basis. The readmission and complication rates at 30 days were 7·1 per cent (633 of 8909) and 10·8 per cent (962 of 8909) respectively. Both readmissions and complications were independently associated with increasing ASA fitness grade, duration of surgery, and increasing numbers of emergency admissions with gallbladder disease before cholecystectomy. No identifiable hospital characteristics were linked to readmissions and complications. Conclusion Readmissions and complications following cholecystectomy are common and associated with patient and disease characteristics

Global burden of chronic respiratory diseases and risk factors, 1990–2019: an update from the Global Burden of Disease Study 2019

Background: Updated data on chronic respiratory diseases (CRDs) are vital in their prevention, control, and treatment in the path to achieving the third UN Sustainable Development Goals (SDGs), a one-third reduction in premature mortality from non-communicable diseases by 2030. We provided global, regional, and national estimates of the burden of CRDs and their attributable risks from 1990 to 2019. Methods: Using data from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019, we estimated mortality, years lived with disability, years of life lost, disability-adjusted life years (DALYs), prevalence, and incidence of CRDs, i.e. chronic obstructive pulmonary disease (COPD), asthma, pneumoconiosis, interstitial lung disease and pulmonary sarcoidosis, and other CRDs, from 1990 to 2019 by sex, age, region, and Socio-demographic Index (SDI) in 204 countries and territories. Deaths and DALYs from CRDs attributable to each risk factor were estimated according to relative risks, risk exposure, and the theoretical minimum risk exposure level input. Findings: In 2019, CRDs were the third leading cause of death responsible for 4.0 million deaths (95% uncertainty interval 3.6–4.3) with a prevalence of 454.6 million cases (417.4–499.1) globally. While the total deaths and prevalence of CRDs have increased by 28.5% and 39.8%, the age-standardised rates have dropped by 41.7% and 16.9% from 1990 to 2019, respectively. COPD, with 212.3 million (200.4–225.1) prevalent cases, was the primary cause of deaths from CRDs, accounting for 3.3 million (2.9–3.6) deaths. With 262.4 million (224.1–309.5) prevalent cases, asthma had the highest prevalence among CRDs. The age-standardised rates of all burden measures of COPD, asthma, and pneumoconiosis have reduced globally from 1990 to 2019. Nevertheless, the age-standardised rates of incidence and prevalence of interstitial lung disease and pulmonary sarcoidosis have increased throughout this period. Low- and low-middle SDI countries had the highest age-standardised death and DALYs rates while the high SDI quintile had the highest prevalence rate of CRDs. The highest deaths and DALYs from CRDs were attributed to smoking globally, followed by air pollution and occupational risks. Non-optimal temperature and high body-mass index were additional risk factors for COPD and asthma, respectively. Interpretation: Albeit the age-standardised prevalence, death, and DALYs rates of CRDs have decreased, they still cause a substantial burden and deaths worldwide. The high death and DALYs rates in low and low-middle SDI countries highlights the urgent need for improved preventive, diagnostic, and therapeutic measures. Global strategies for tobacco control, enhancing air quality, reducing occupational hazards, and fostering clean cooking fuels are crucial steps in reducing the burden of CRDs, especially in low- and lower-middle income countries